A systematic review and meta-analysis of pteridines in mild cognitive impairment and Alzheimer's disease.

ABSTRACT:

Background

Alterations in specific pteridine metabolites, particularly neopterin, biopterin, and tetrahydrobiopterin have been reported in mild cognitive impairment, Alzheimer's disease, and other types of dementia. However, the available evidence regarding such alterations has not been comprehensively and critically appraised.

Methods

We systematically reviewed studies reporting the concentrations of biopterin, tetrahydrobiopterin, and neopterin in different biological fluids in patients with mild cognitive impairment, Alzheimer's disease or other types of dementia, and healthy controls. Electronic databases were searched from inception to 29 February 2024.

Results

Overall, there were no significant differences in plasma/serum concentrations of neopterin between pati

SUBMITTER: Mangoni AA 

PROVIDER: S-EPMC11823259 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature