Enhanced hemostatic efficacy of cryogel with copper ion-loaded mesoporous bioactive glasses for acute and persistent bleeding.

ABSTRACT: Uncontrolled acute and persistent bleeding, as well as with infection, is a great challenge because of the high mortality during treating the patients with injuries, complex surgery or bone marrow failure. Here, we develop an external form of natural components which is based on phosphorylated methacrylated gelatin (GelMA, G) cryogel (GP) loaded with tannic acid (TA)-mixed copper ion (Cu²⁺) mesoporous bioactive glasses (MBG), named after GP@MBG-Cu-TA cryogel, to address the goals of reduce persistent bleeding and enhance antibacterial activity. Structurally, GP@MBG-Cu-TA cryogel is based on GP, MBG loaded with TA and Cu²⁺ adheres to GP via hydrogen bonding. In vitro, GP@MBG-Cu-TA cryogel displays a good biocompatibility, hemostatic and antimicrobial capability. In viv

SUBMITTER: Hou Q 

PROVIDER: S-EPMC11823261 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature