Flexible inner surface of polysulfone membranes prevents platelet adhesive protein adsorption and improves antithrombogenicity in vitro.

ABSTRACT:

Background

We investigated whether the condition of the inner surface of hollow fibers affects the blood compatibility of hemodialyzers.

Methods

We used scanning probe microscope/atomic force microscopy (SPM/AFM) to investigate the height of the swelling and flexible layers (thickness and softness) on the inner surfaces of the hollow fibers. Next, we tested the blood compatibility between dialyzers comprising a hollow fiber membrane, in which the other dialyzers, except for PVP, were additionally coated using PS membranes coated with other materials. After blood was injected into the dialyzer and plugged, dynamic stimulation was performed by slightly rotating the dialyzer for 4 h, although there was no blood circulation.

Results

The vitamin E-coated polysulfone (PS) m

SUBMITTER: Takatsuji R 

PROVIDER: S-EPMC11823271 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature