Photoreceptor layer elevation due to subretinal fluid: Impact on visual acuity measurements and simulation from biometrics.

ABSTRACT:

Purpose

Visual acuity (VA) is a primary outcome measure that defines the success of clinical interventions for retinal diseases such as age-related macular degeneration (AMD) or diabetic macular oedema (DME). These conditions can lead to the presence of subretinal fluid, causing substantial photoreceptor layer elevation. Hyperopic defocus then occurs, affecting the VA measurements. In this study, we simulated the induced hyperopic shift for real-world values of photoreceptor layer elevation and measured the effect on VA measurements.

Methods

To simulate the hyperopic shift, we used a four-surface eye model. To measure the effect of defocus on VA, normally sighted adults (N = 44, mean [SD] age = 32 [13.0] year, range: 21-71 year) performed four test conditions, that is, defoc

SUBMITTER: Parimi V 

PROVIDER: S-EPMC11823303 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature