Pediatric kidney transplant recipients are at an increased risk for dysbiosis.

ABSTRACT:

Introduction

This study aimed to compare the gut microbiota composition in pediatric kidney transplant (KTx) recipient with that of healthy children.

Methods

This cross-sectional observational study included 30 pediatric KTx recipients aged between 7 and 21 years and 25 healthy children. The gut microbiota was assessed using 16S rRNA gene sequencing, with alpha and beta diversity, as well as all statistical analyses, conducted using the Phyloseq library in the R programming language. Taxonomic profiles were evaluated with QIIME2, and differences in gut microbiota profiles were compared using linear discriminant analysis effect size (LEFSe) with an LDA threshold of >2 and p < 0.05.

Results

No significant differences were found in alpha and beta diversity between

SUBMITTER: Yılmaz G 

PROVIDER: S-EPMC11823477 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature