Protein Orientation and Polymer Phase Separation Induced by Poly(methyl methacrylate) Tacticity.

ABSTRACT: Stereochemistry may affect the physicochemical and biological properties of polymer films that are important for their applications, including substrates for the fabrication of protein microarrays. In this study, we investigated the effect of poly(methyl methacrylate) (PMMA) tacticity on the interaction of polymer thin films with proteins and on the phase separation process in blends with poly(tert-butyl methacrylate) (PtBMA). Thin films of isotactic, atactic, and syndiotactic PMMA were studied for topography, surface chemistry, and protein adsorption. Secondary ion mass spectrometry and contact angle measurements revealed a lower surface exposure of polar ester functional groups for iso-PMMA, resulting in the reduced adsorption of albumin and fibrinogen proteins. We also showed tha

SUBMITTER: Janiszewska N 

PROVIDER: S-EPMC11823595 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature