Emergence of antibiotic-specific <i>Mycobacterium tuberculosis</i> phenotypes during prolonged treatment of mice.

ABSTRACT: A major challenge in tuberculosis (TB) therapeutics is that antibiotic exposure leads to changes in the physiology of M. tuberculosis (Mtb), which may enable the pathogen to withstand treatment. While antibiotic-treated Mtb has been evaluated in in vitro experiments, it is unclear if and how long-term in vivo treatment with diverse antibiotics with varying treatment-shortening activity (sterilizing activity) affects Mtb physiologic processes differently. Here, we used SEARCH-TB, a pathogen-targeted RNA-sequencing platform, to characterize the Mtb transcriptome in the BALB/c high-dose aerosol infection mouse model following 4 weeks of treatment with three sterilizing and three non-sterilizing antibiotics. Certain transcriptional change

SUBMITTER: Wynn EA 

PROVIDER: S-EPMC11823617 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature