Modification of Liposomal Properties by an Engineered Gemini Surfactant.

ABSTRACT: Lipid membranes form the primary structure of cell membranes and serve as configurable interfaces across numerous applications including biosensing technologies, antifungal treatments, and therapeutic platforms. Therefore, the modification of lipid membranes by additives has important consequences in both biological processes and practical applications. In this study, we investigated a nicotinic-acid-based gemini surfactant (NAGS) as a chemically tunable molecular additive for modulating the structure and phase behavior of liposomal membranes. We specifically focused on NAGS with hydrocarbon chains that mirror those of lipid molecules. By introducing NAGS to phosphatidylcholine membranes with lipids of identical and varied chain lengths or degrees of unsaturation, we demonstrated the effec

SUBMITTER: Eftaiha AF 

PROVIDER: S-EPMC11823631 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature