A gene signature related to programmed cell death to predict immunotherapy response and prognosis in colon adenocarcinoma.

ABSTRACT:

Background

Tumor development involves the critical role of programmed cell death (PCD), but the correlation between colon adenocarcinoma (COAD) and PCD-related genes is not clear.

Methods

Subtyping analysis of COAD was performed by consensus clustering based on The Cancer Genome Atlas (TCGA), with the AC-ICAM queue from the cBioportal database as a validation set. Immune infiltration of the samples was evaluated using CIBERSORT and Microenvironment Cell Populations (MCP)-counter algorithms. Patients' immunotherapy response was predicted by the TIDE and aneuploidy scores. Pathway enrichment analysis was conducted with gene set enrichment analysis (GSEA). A RiskScore model was established with independent prognostic PCD-related genes filtered by Cox regression analysis. The ma

SUBMITTER: Zheng L 

PROVIDER: S-EPMC11823652 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature