The association between serum lipids at diagnosis and renal outcome in microscopic polyangiitis patients.

ABSTRACT:

Objectives

Microscopic polyangiitis (MPA) is a subgroup of ANCA-associated vasculitis (AAV), which is characterized by vascular endothelial cell damage caused by abnormally activated neutrophils. Dyslipidemia is associated with vascular endothelial cell injury, and the relationship between blood lipid levels and renal prognosis in MPA patients is not clear. We aim to investigate the correlation between blood lipid levels at diagnosis and renal prognosis in MPA patients.

Methods

Firstly, we retrospectively included 110 patients diagnosed with MPA and the primary endpoint was the occurrence of end stage renal disease (ESRD). The association between blood lipids at diagnosis and renal outcome was evaluated with Cox regression analysis and survival analysis. Secondly, we explore

SUBMITTER: Zheng Z 

PROVIDER: S-EPMC11823655 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature