Evidence of dissemination of a <i>clc</i>-type integrative and conjugative element to <i>Stenotrophomonas maltophilia</i>, mediating acquisition of <i>sul1</i> and other resistance determinants.

ABSTRACT: A Stenotrophomonas maltophilia strain positive for the bla_VIM-1 metallo-beta-lactamase gene and resistant to trimethoprim-sulfamethoxazole was unexpectedly isolated from a surveillance rectal swab. The characterization of the strain revealed carriage of a 91 kb integrative and conjugative element (ICE) harboring several resistance determinants [sul1, bla_VIM-1, aac(6')-Ib, aac(6')-31, qacE∆1, cld, and merEDAPTR], closely related with a group of clc-type ICEs widespread among Pseudomonas aeruginosa and other pseudomonads. Results highlighted the possible spreading of similar elements to S. maltophilia, mediating the acquisition of relevant resistances.

SUBMITTER: Boncompagni SR 

PROVIDER: S-EPMC11823659 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature