Imbalance in redox status is associated with tumor aggressiveness and poor outcome in lung adenocarcinoma patients.

ABSTRACT:

Purpose

The expression levels of human antioxidant genes (HAGs) and oxidative markers were investigated in light of lung adenocarcinoma aggressiveness and patient outcome.

Methods

We assayed in vitro the tumoral invasiveness and multidrug resistance in human lung adenocarcinoma (AdC) cell lines (EKVX and A549). Data were associated with several redox parameters and differential expression levels of HAG network. The clinicopathological significance of these findings was investigated using microarray analysis of tumor tissue and by immunohistochemistry in archival collection of biopsies.

Results

An overall increased activity (expression) of selected HAG components in the most aggressive cell line (EKVX cells) was observed by bootstrap and gene set enrichment analysis (G

SUBMITTER: Lisboa da Motta L 

PROVIDER: S-EPMC11823786 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature