Association between MutL homolog 1 polymorphisms and the risk of colorectal cancer: a meta-analysis.

ABSTRACT:

Purpose

As one of the most essential components of mismatch repair system, MutL homolog 1 (MLH1) plays an increasingly implicated role in initiation and promotion of colorectal carcinogenesis, with germ-line mutations in different loci. However, whether a single genetic variant in MLH1 could predict the risk of cancer was still under doubt and recent studies yielded inconsistent results. Therefore, this meta-analysis aimed at investigating the association between MLH1 single-nucleotide polymorphisms (SNPs) and colorectal cancer (CRC) risks.

Methods

A systematic literature search of PubMed, MEDLINE, Web of Science and BIOSIS databases was performed to obtain all available SNPs and studies. We focused on three SNPs (rs1800734, rs1799977 and rs63750448) with the most included s

SUBMITTER: Chen H 

PROVIDER: S-EPMC11823809 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature