Meta-analysis of the association between hOGG1 Ser326Cys polymorphism and risk of colorectal cancer based on case--control studies.

ABSTRACT:

Purpose

Oxidative DNA damage caused by reactive oxygen species plays an important role in cancer development. The association between colorectal cancer and hOGG1 Ser326Cys polymorphisms has been analyzed in several published studies, but mixed findings have been reported. The main purpose of this study was to integrate previous results and explore whether the polymorphism of hOGG1 is associated with susceptibility to colorectal cancer.

Methods

PubMed, Embase, Google Scholar, and Cbmdisc were searched for studies on the relationship of hOGG1 SNPs and the incidence of colorectal cancer (CRC). Eligible articles were included for data extraction. The main outcome was the frequency of hOGG1 Ser326Cys polymorphisms between cases and controls. Comparison of the distribution of SNP

SUBMITTER: Guo CL 

PROVIDER: S-EPMC11824162 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature