Intron 3 of the ARID5B gene: a hot spot for acute lymphoblastic leukemia susceptibility.

ABSTRACT:

Purpose

Single-nucleotide polymorphisms (SNPs) in AT-rich interactive domain 5B (ARID5B) have been associated with risk for pediatric acute lymphoblastic leukemia (ALL). After reviewing previous studies, we realized that the most significant associations were restricted to intron 3, but the mechanism(s) by which those SNPs affect ALL risk remain to be elucidated. Therefore, the aim of this study was to analyze the association between genetic variants of the intron 3 region of ARID5B and the incidence of B-ALL in a Spanish population. We also aimed to find a functional explanation for the association, searching for copy number variations (CNVs), and changes in ARID5B expression associated with the genotypes of the SNPs.

Methods

We analyzed 10 SNPs in intron 3 of ARID5B in a S

SUBMITTER: Gutierrez-Camino A 

PROVIDER: S-EPMC11824183 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature