Eye Movement and Gait Variability Analysis in Chinese Patients With Huntington's Disease.

ABSTRACT:

Objective

Huntington's disease (HD) is characterized by motor, cognitive, and neuropsychiatric symptoms. Oculomotor impairments and gait variability have been independently considered as potential markers in HD. However, an integrated analysis of eye movement and gait is lacking. We performed multiple examinations of eye movement and gait variability in HTT mutation carriers, analyzed the consistency between these parameters and clinical severity, and then examined the associations between oculomotor impairments and gait deficits.

Methods

We included 7 patients with pre-HD, 30 patients with HD and 30 age-matched controls. We collected demographic data and assessed the Unified Huntington's Disease Rating Scale (UHDRS) score. Examinations, including saccades, smooth pursuit te

SUBMITTER: Qian SX 

PROVIDER: S-EPMC11824514 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature