Predictive value of sphingosine kinase 1 expression in neoadjuvant treatment of breast cancer.

ABSTRACT:

Purpose

Sphingolipids play important roles in apoptosis and cell proliferation. Sphingosine kinase 1 (SphK1) expression has a prognostic impact in primary breast cancer, but its predictive value is currently unknown.

Methods

A total of 112 breast cancer specimens from a prospective neoadjuvant chemotherapy trial (GeparDuo) were studied. Using tissue microarrays of pre-treatment core cut biopsies, we determined the expression of SphK1 by immunohistochemistry. The upper quartile of the cohort according to an immune reactive score of SphK1 was used as cutoff for high expression.

Results

We observed a larger number of samples with high SphK1 expression among ER-negative cancers (36.8 vs. 20.5 % among ER-positive cancers; Fisher test p = 0.073). Eighteen of the 112 patient

SUBMITTER: Ruckhaberle E 

PROVIDER: S-EPMC11824557 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature