Variant of Uncertain Significance Patterns among Patients with Early-Onset Colorectal Cancer.

ABSTRACT:

Abstract

The increasing burden of colorectal cancer among adults younger than age 50 years (early-onset colorectal cancer) and new National Comprehensive Cancer Network guidelines recommending universal genetic testing in early-onset colorectal cancer emphasize the need for accurate and timely variant classification in clinical care. In this study, we investigated germline variant of uncertain significance (VUS) patterns among diverse individuals with early-onset colorectal cancer. A total of 3,980 individuals ages 15 to 49 years when diagnosed with a first primary colorectal cancer, including 1,001 cases identifying as non-White, who underwent genetic testing for 14 colorectal cancer susceptibility genes performed by a clinical testing laboratory were included. A five-tier classif

SUBMITTER: Francis RA 

PROVIDER: S-EPMC11824576 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature