Utilization of Acid Suppressants After Withdrawal of Ranitidine in Korea: An Interrupted Time Series Analysis.

ABSTRACT:

Objectives

This study was performed to evaluate the utilization patterns of acid suppressants following the withdrawal of ranitidine in Korea.

Methods

Health Insurance Review & Assessment Service (HIRA) data from January 2016 to May 2023 were utilized to assess the usage of histamine H2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) for acid-related diseases. Drug utilization was calculated for each agent based on the defined daily dose (DDD). To evaluate changes in utilization following the ranitidine recall, an interrupted time series analysis was conducted using segmented linear regression and an autoregressive integrated moving average model.

Results

Before the withdrawal of ranitidine, the DDD per 100 000 inhabitants per day was increasing by

SUBMITTER: Choi JP 

PROVIDER: S-EPMC11824620 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature