TNF-β +252 A>G polymorphism and susceptibility to cancer.

ABSTRACT:

Objective

Tumor necrosis factor-β (TNF-β) plays important roles in mediating cancer development. Many studies have argued possible associations of TNF-β +252 A>G polymorphism with different cancers. However, association between this most frequently studied polymorphism and susceptibility to cancer still remains controversial and ambiguous. The aim of this study is to determine the relationship of TNF-β +252 A>G polymorphism with cancer through meta-analysis.

Methods

Electronic searches of several databases were conducted for all publications on the associations between this variant and cancer through October 2011. Odds ratios (ORs) with 95 % confidence intervals (95 % CIs) were used to access the strength of this association in random-effect model.

Results

Thirty-thre

SUBMITTER: Yang L 

PROVIDER: S-EPMC11824764 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature