Antidiabetic Potential of Senna siamea: α-Glucosidase Inhibition, Postprandial Blood Glucose Reduction, Toxicity Evaluation, and Molecular Docking.

ABSTRACT: Senna siamea (Lam.) H.S. Irwin & Barneby is used in Thai cuisine. This plant is also used in traditional treatments, including diabetes. Therefore, this study aims to examine the antihyperglycemic effects of S. siamea heartwood extract. The ethanolic extract of S. siamea heartwood exhibited activity against α-glucosidase enzyme with IC₅₀ values of 54.4 μg/mL. Moreover, S. siamea extract (250-1000 mg/kg BW) was tested using normal rats with and without sucrose of 3 g/kg BW administration. The results showed that all extract concentrations significantly reduced fasting blood glucose compared with the control. In addition, results also agreed with the amount of sucrose in the small intestine of rats. In the acute toxicity study, a single dose of t

SUBMITTER: Sangkanu S 

PROVIDER: S-EPMC11824848 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature