Oral oxycodone self-administration leads to features of opioid misuse in male and female mice.

ABSTRACT: Use of prescription opioids, particularly oxycodone, is an initiating factor driving the current opioid epidemic. There are several challenges with modelling oxycodone abuse. First, prescription opioids including oxycodone are orally self-administered and have different pharmacokinetics and dynamics than morphine or fentanyl, which have been more commonly used in rodent research. This oral route of administration determines the pharmacokinetic profile, which then influences the establishment of drug-reinforcement associations in animals. Moreover, the pattern of intake and the environment in which addictive drugs are self-administered are critical determinants of the levels of drug intake, of behavioural sensitization and of propensity to relapse behaviour. These are all important consider

SUBMITTER: Slivicki RA 

PROVIDER: S-EPMC11824864 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature