Efficacy of Noninvasive Ventilation With Expiratory Washout in Stable COPD Patients.

ABSTRACT: Background: A noninvasive ventilation (NIV) mask has been designed to deliver NIV with expiratory washout to improve efficacy of ventilation by optimizing clearance of expired gases from the anatomic dead space. This study compared the performance and comfort of a novel investigational mask with expiratory washout with a conventional mask during NIV therapy. Methods: In this pilot crossover study, participants with severe stable COPD attended a single visit to receive bi-level NIV through 2 masks; the investigational mask with expiratory washout and a conventional mask. The order of mask use was randomly allocated, and each mask was used for 60 min with a 30-60-min washout in between. The primary outcome was transcutaneous carbon dioxide at 60 min. Other physiologic and NIV d

SUBMITTER: Kung S 

PROVIDER: S-EPMC11824877 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature