Depression and physical multimorbidity: A cohort study of physical health condition accrual in UK Biobank.

ABSTRACT:

Background

Depression is associated with a range of adverse physical health outcomes. We aimed to quantify the association between depression and the subsequent rate of accrual of long-term physical health conditions in middle and older age.

Methods and findings

We included 172,556 participants from the UK Biobank (UKB) cohort study, aged 40-71 years old at baseline assessment (2006-2010), who had linked primary care data available. Using self-report, primary care, hospital admission, cancer registry, and death records, we ascertained 69 long-term physical health conditions at both UKB baseline assessment and during a mean follow-up of 6.9 years. We used quasi-Poisson models to estimate associations between history of depression at baseline and subsequent rate of physical co

SUBMITTER: Fleetwood KJ 

PROVIDER: S-EPMC11825000 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature