Current and emerging approaches to cochlear immunosuppression with translation to human inner ear stem cell therapy: A systematic review.

ABSTRACT: Hearing loss is a significant health burden across all stages of life. One in 5 people suffer hearing loss, with 5% of the world's population experiencing disabling hearing loss. A large proportion of this loss is the consequence of damage or loss of neurosensory structures, termed "sensorineural" hearing loss. A recent advance in the treatment of sensorineural hearing loss has occurred, with the advent of inner ear stem cell therapy. Focus has pivoted from augmenting existing neural structures to regenerating neural frameworks. To date, stem cell therapy is limited by the host immune system and rejection of donor cells. A better understanding of immunity in the inner is ear required to progress stem cell therapy for hearing loss. This review outlines a contemporary understanding of the in

SUBMITTER: Creber NJ 

PROVIDER: S-EPMC11825040 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature