Optimizing mechanical ventilation: Personalizing mechanical power to reduce ICU mortality - a retrospective cohort study.

ABSTRACT:

Background

Mechanical ventilation, a crucial intervention for acute respiratory distress syndrome (ARDS), can lead to ventilator-induced lung injury (VILI). This study focuses on individualizing mechanical power (MP) in mechanically ventilated patients to minimize VILI and reduce ICU mortality.

Methods

A retrospective analysis was conducted using the Amsterdam University Medical Centers Database (AmsterdamUMCdb) data. The study included patients aged 18 and older who needed at least 48 hours of pressure-controlled mechanical ventilation. Patients who died or were extubated within 48 hours and those with inadequate data were excluded. Patients were categorized into hypoxemia groups based on their PaO2/FiO2 ratio. MP was calculated using a surrogate formula and normalized to i

SUBMITTER: Alkhalifah AS 

PROVIDER: S-EPMC11825045 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature