Whole tissue proteomic analyses of cardiac ATTR and AL unveil mechanisms of tissue damage.

ABSTRACT:

Background

Cardiac AL and ATTR are potentially fatal cardiomyopathies. Current therapies do not address mechanisms of tissue dysfunction because these remain unknown. Our prior work focused on the amyloid plaque proteome, which may not capture tissue-wide proteomic alterations.

Objectives

To evaluate mechanisms of tissue dysfunction in cardiac AL and ATTR using a full biopsy tissue proteomics approach.

Methods

We performed proteomics analysis on 76 ATTR and 27 AL diagnostic endomyocardial biopsies.

Results

Stage-3 AL patients exhibited increased coagulation, extracellular matrix remodelling (ECM), epithelial-to-mesenchymal transition (EMT), complement activation, hypoxia, and clathrin-mediated endocytosis pathways vs. stages-1/2, with decreased healthy c

SUBMITTER: Netzel BC 

PROVIDER: S-EPMC11825277 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature