High-resolution Cryo-EM Structure Determination of a-Synuclein-A Prototypical Amyloid Fibril.

ABSTRACT: The physiological role of a-synuclein (a-syn), an intrinsically disordered presynaptic neuronal protein, is believed to impact the release of neurotransmitters through interactions with the SNARE complex. However, under certain cellular conditions that are not well understood, a-syn will self-assemble into β-sheet-rich fibrils that accumulate and form insoluble neuronal inclusions. Studies of patient-derived brain tissues have concluded that these inclusions are associated with Parkinson's disease, the second most common neurodegenerative disorder, and other synuclein-related diseases called synucleinopathies. In addition, repetitions of specific mutations to the SNCA gene, the gene that encodes a-syn, result in an increased disposition for synucleinopathies. The latest advances in cryo-EM

SUBMITTER: Sanchez JC 

PROVIDER: S-EPMC11825309 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature