Association between folate and glutamine metabolism and prognosis of kidney cancer.

ABSTRACT:

Background

Recent studies have shown that folate metabolism might influence cancer progression by regulating mitochondrial metabolism and glutamine is involved in the development and progression of several malignancies. This study aimed to explore the association between folate and glutamine metabolism and prognosis of kidney cancer.

Methods

We performed expression analysis, survival analysis, genetic alteration analysis, and tumor immune infiltrate analysis of related genes using platforms such as UALCAN, GEPIA, GEPIA2, cBioPortal, and TIMER. Serum folate, vitamin B12, and methylmalonic acid levels and clinical information of participants in the United States diagnosed with kidney cancer was obtained from the National Health and Nutrition Examination Survey (NHANES) and ana

SUBMITTER: Qin J 

PROVIDER: S-EPMC11825324 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature