Prognosis of nodal micrometastasis in resectable pN0 non-small cell lung cancer.

ABSTRACT:

Background

Nodal micrometastasis (NMM) is the presence of a small cluster of tumor cells in a regional lymph node. However, the prognostic value of NMM in resectable NSCLC is still debated.

Methods

This retrospective cohort study at Maharaj Nakorn Chiang Mai Hospital from 2006 to 2017 assesses the prognostic impact of nodal micrometastasis in resectable pN0 NSCLC patients, using immunohistochemistry staining for cytokeratin AE1/AE3, p53, and BerEp4. Patients are categorized into three groups: pN0 without nodal micrometastasis, pN0 with nodal micrometastasis, and pN+. Overall survival is the primary endpoint, with disease-free survival as the secondary endpoint.

Results

Out of 225 patients, 98 had pathological N0 (pN0) status and 127 had pathological N positive (pN+) s

SUBMITTER: Siwachat S 

PROVIDER: S-EPMC11825345 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature