Cerebral magnetic resonance spectroscopy - insights into preterm brain injury.

ABSTRACT:

Objective

Magnetic resonance spectroscopy (¹H-MRS) may provide clinically relevant data regarding metabolic processes that govern the course of preterm brain injury.

Study design

46 very preterm infants (VP) were evaluated by magnetic resonance imaging and ¹H-MRS at term-equivalent age. Brain injury was assessed according to the Kidokoro scale. Moreover, 17 term-born infants with hypoxic-ischemic encephalopathy (HIE) were scanned. The metabolic profile of the central nervous system was obtained from the bilateral thalamus.

Result

The Lipids/Creatine, Choline/Creatine, N-acetyl aspartate/Choline, Lactate/N-acetyl aspartate, and Lactate/Creatine ratios differed between VP infants with moderate+severe brain damage and those without brain injury. Mor

SUBMITTER: Zasada M 

PROVIDER: S-EPMC11825355 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature