Time-on-task-related decrements in performance in the rodent continuous performance test are not caused by physical disengagement from the task.

ABSTRACT: Attention deficits, a hallmark of many neuropsychiatric disorders, significantly impair quality of life and functional outcome for patients. Continuous Performance Tests (CPTs) are widely used to assess attentional function in clinical settings and have been adapted for mice as the rodent Continuous Performance Test (rCPT). In this study, we combined traditional analyses of rCPT performance with markerless pose estimation using DeepLabCut and visual field analysis (VFA) to objectively measure the orientation of mice toward stimuli during rCPT sessions. Additionally, we extended the session length to assess performance decrements over time. Our findings show that extending rCPT sessions from 45-90 min results in a significant decline in performance in male mice, which aligns with performanc

SUBMITTER: Li Y 

PROVIDER: S-EPMC11825365 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature