Analysis of microarray and single-cell RNA-seq identifies gene co-expression, cell-cell communication, and tumor environment associated with metabolite interconversion enzyme in prostate cancer.

ABSTRACT:

Background

Prostate cancer (PCa) is the second most common malignant neoplasm in males and is the fifth leading cause of cancer-related mortality. Due to the use of prostate-specific antigen (PSA) screening and improved biopsy techniques, persons identified with early-stage prostate cancer often have a positive prognosis after comprehensive treatment. Nonetheless, prostate cancer is a latent illness that may present as an asymptomatic tumor in individuals aged 20-30. The overall survival (OS) of men with advanced PCa is significantly diminished. Consequently, there is an immediate want for innovative, accurate biomarkers to detect early prostate cancer.

Methods

This research analyzed the interaction network of differentially expressed genes (DEGs) related to metabolite inter

SUBMITTER: Hashemi Karoii D 

PROVIDER: S-EPMC11825437 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature