The clinical significance of T cell infiltration and immune checkpoint expression in central nervous system germ cell tumors.

ABSTRACT:

Background

Primary central nervous system germ cell tumors (CNS GCTs) are rare intracranial malignancies, and their tumor microenvironment plays a crucial role in tumor initiation and progression. However, the specific characteristics of the immune microenvironment and their clinical significance remain poorly understood.

Methods

This study included 93 paraffin-embedded tissue samples from 90 patients diagnosed with CNS GCTs. Immunohistochemistry and immunofluorescence staining were used to assess the infiltration patterns of T cell subsets (CD3+, CD4+, CD8+, Foxp3+) and the expression levels of immune checkpoints (CTLA-4, PD-1, PD-L1). Additionally, the study explored the relationship between these immune features and the patient's clinical characteristics and prognosis.

SUBMITTER: Zhou J 

PROVIDER: S-EPMC11825448 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature