SIRI and SII as potential biomarkers of disease activity and lupus nephritis in systemic lupus erythematosus.

ABSTRACT:

Objectives

Inflammation is important in the development of systemic lupus erythematosus (SLE). Systemic inflammation response index (SIRI) and systemic immune-inflammation index (SII) are novel clinical markers of inflammation with prognostic value in different diseases. However, the value of SIRI and SII as inflammation predictors in SLE remains unclear. This study explores the SIRI and SII as potential biomarkers for SLE.

Methods

Data from 280 individuals, including newly diagnosed SLE patients and healthy controls, were collected and divided into three groups: SLE without lupus nephritis (NLN) group (n=93), lupus nephritis (LN) group (n=96) and healthy control group (n=91). Differences in SIRI and SII among the three groups were compared. Logistic regression and Pearson l

SUBMITTER: Yang CH 

PROVIDER: S-EPMC11825474 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature