Conserved long noncoding RNA TILAM promotes liver fibrosis through interaction with PML in HSCs.

ABSTRACT:

Background and aims

Fibrosis is the common end point for all forms of chronic liver injury, and the progression of fibrosis leads to the development of end-stage liver disease. Activation of HSCs and their transdifferentiation into myofibroblasts results in the accumulation of extracellular matrix proteins that form the fibrotic scar. Long noncoding RNAs regulate the activity of HSCs and provide targets for fibrotic therapies.

Approach and results

We identified long noncoding RNA TILAM located near COL1A1 , expressed in HSCs, and induced with liver fibrosis in humans and mice. Loss-of-function studies in human HSCs and human liver organoids revealed that TILAM regulates the expression of COL1A1 and other extracellular matrix genes. To determine the role of TILAM in vivo, we

SUBMITTER: Sun C 

PROVIDER: S-EPMC11825499 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature