Clinical evaluation of breast cancer tissue with optical coherence tomography: key findings from a large-scale study.

ABSTRACT:

Purpose

Breast cancer patients undergoing breast-conserving surgery may require a second operation if positive margins persist but current intraoperative methodologies often lack real-time and comprehensive assessments of tissue margins. This study addresses this critical gap by introducing a novel approach to enhance margin assessment in breast surgery.

Methods

A total of 252 fresh tissue blocks from 199 patients with different types of breast lesions were scanned with a customized swept-source optical coherence tomography (SS-OCT) system, and the OCT features of normal, benign, and malignant breast tissues, were systematically analyzed.

Results

The qualitative analysis results revealed that adipose tissue has high penetration depth and a typical honeycomb pattern, w

SUBMITTER: Liu X 

PROVIDER: S-EPMC11825538 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature