Relationship of left piriform cortex network centrality with temporal lobe epilepsy duration and drug resistance.

ABSTRACT:

Background

We investigated the relationship of piriform cortex (PC) structural network centrality with drug resistance and epilepsy duration as markers of sustained epileptic activity.

Methods

PCs were manually delineated on retrospectively collected 3D-T1-MRI images of patients with temporal lobe epilepsy (TLE). Connectomes were computed from diffusion MRI scans, including the PC as network nodes. Betweenness centrality (BC) and node degree were computed and compared across drug-resistant versus drug-sensitive patients. Correlations of centrality metrics with the duration of epilepsy were calculated.

Results

Sixty-two patients (36 females, 43/62 drug-resistant) were included in the main analysis. Greater centrality of the left PC was associated with drug resistance (

SUBMITTER: Zahnert F 

PROVIDER: S-EPMC11825592 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature