Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels.

ABSTRACT: Increased dietary inorganic phosphate (P_i) intake stimulates renal P_i excretion, in part, by parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23) or dopamine. High dietary P_i may also stimulate sympathetic outflow. Rodent studies provided evidence for these regulatory loops, while controlled experiments in healthy humans examined periods of either a few hours or several weeks, and often varied dietary calcium intake. The effects of controlled, isolated changes in dietary P_i intake over shorter periods are unknown. We studied the effects of a low or high P_i diet on parameters of mineral metabolism in 10 healthy young men. Participants received a standardized diet (1000 mg phosphorus equivalent/day) supplemented with either a p

SUBMITTER: Gerber JS 

PROVIDER: S-EPMC11825603 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature