Optimal interventions for low anterior resection syndrome: Bayesian network meta-analysis of randomized controlled trials.

ABSTRACT:

Background

The optimal intervention for managing low anterior resection syndrome (LARS) remains uncertain. This Bayesian network meta-analysis was conducted to compare and rank the effectiveness of various interventions on LARS.

Methods

Randomized controlled trials (RCTs) addressing interventions for LARS were extracted from six electronic databases until September 2023. A network meta-analysis was performed using a Bayesian random-effects and consistency model. The results were presented as mean differences (MDs) with credible interval (CrI) or standardized mean differences (SMDs) with CrI.

Results

A total of 11 RCTs were included. In the short term (≤ 6 months), transanal irrigation (TAI) had significant positive impacts on overall LARS symptoms (MD (95% CrI) -14.13

SUBMITTER: Yu M 

PROVIDER: S-EPMC11825619 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature