Household transmission of Omicron variant of SARS-CoV-2 under conditions of hybrid immunity-a prospective study in Germany.

ABSTRACT:

Purpose

We investigated the protection offered by vaccinations and previous infections for the household transmission of Omicron variant of SARS-CoV-2.

Methods

34,666 participants of the German DigiHero cohort study with two or more household members were invited to a prospective household transmission study between June and December 2022. In case of a positive SARS-CoV-2 test in a household, symptom diaries were completed for at least 14 days. Dry blood spots (DBS) were taken from all household members at the beginning and six to eight weeks later. DBS were analyzed for SARS-CoV-2 antibodies.

Results

1191 individuals from 457 households participated. The risk of acquiring a SARS-CoV-2 infection decreased with higher S-titer levels at the time of exposure (from 80% at

SUBMITTER: Klee B 

PROVIDER: S-EPMC11825627 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature