Unravelling the Association Between Uncertainties in Model-based Economic Analysis and Funding Recommendations of Medicines in Australia.

ABSTRACT:

Objective

Health technology assessment is used extensively by the Pharmaceutical Benefits Advisory Committee (PBAC) to inform medicine funding recommendations in Australia. The PBAC often does not recommend medicines due to uncertainties in economic modelling that result in delaying access to medicines for patients. The systematic identification of which uncertainties can be reduced with alternative evidence or the collection of additional data can help inform recommendations. This study aims to characterise different types of uncertainty in economic models and empirically assess their association with the PBAC recommendations.

Methods

A framework was developed to characterise four types of uncertainties: methodological, structural, generalisability and parameter uncertainty

SUBMITTER: Chen Q 

PROVIDER: S-EPMC11825629 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature