Phase equilibria and drug partitioning ability of betaine based aqueous two-phase systems.

ABSTRACT: The aqueous two-phase system (ATPS) as an environmentally friendly technique has a high potential for extraction of drugs, proteins, metals, etc. In this work first the formation of ATPSs by betaine, which is a novel, low toxic, and high biodegradable material, and polyethylene glycol or phosphate salts (K₃PO₄ and K₂HPO₄) were investigated temperatures of 298.15, 308.15, 318.15 K and atmospheric pressure (≈ 85 kPa). The effect of increasing temperature on the binodal curves was investigated. The experimental binodal data were correlated using two empirical nonlinear three parameter expressions developed by Merchuk, and Zafarani-Moattar et al. and the two-parameter modified equation derived from effective excluded volume theory. Then, the experime

SUBMITTER: Zafarani-Moattar MT 

PROVIDER: S-EPMC11825666 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature