Differential association of selenium exposure with insulin resistance and β-cell function in middle age and older adults.

ABSTRACT:

Objective

To assess whether the role of selenium on pre-diabetes is differential by age, given comorbidities and decreased β-cell function in older adults.

Research design and methods

We evaluated the cross-sectional association of blood selenium with the homeostatic model assessment for insulin resistance (HOMA-IR) and β-cell function (HOMA-β) in middle-aged (Aragon Workers Health Study [AWHS], N = 1186), and older (Seniors ENRICA [Study on Nutrition and Cardiovascular Risk in Spain]-2 [SEN-2], N = 915) diabetes-free adults. A subsample of participants from AWHS (N = 571) and SEN-2 (N = 603) had glucose and insulin repeated measurements for longitudinal analysis. We validated the cross-sectional dose-response associations in the 2011-2018 National Health and Nutrition Exami

SUBMITTER: Rodriguez-Hernandez Z 

PROVIDER: S-EPMC11825691 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature