Genomic diversity and comparative phylogenomic analysis of genus Norovirus.

ABSTRACT: Noroviruses consist of ten genogroups, five of which (GI, GII, GIV, GVIII, GIX) infect humans. Noroviruses are traditionally classified based on the VP1 (genotype), RdRP (P-type), or dual-typing nomenclature. However, current classifications solely relying on specific proteins may be insufficient to represent the evolutionary history due to their recombination events. Thus, it is challenging to identify the dual-types in environmental or stool samples co-infected with more than two types using the existing system. We performed a comprehensive genomic analysis using ten assembled genomes with 1417 genomes from NCBI. Our study provides a detailed examination of the genomic characteristics of norovirus and the criteria for current genotypes and P-types. The phylogenomic analysis revealed two

SUBMITTER: Doh H 

PROVIDER: S-EPMC11825734 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature