Evaluation of a new human immunodeficiency virus antigen and antibody test using light-initiated chemiluminescent assay.

ABSTRACT:

Objectives

The goal of this study is to evaluate the analytical and clinical performance of a new human immunodeficiency virus antigen and antibody (HIV Ag/Ab) test using light-initiated chemiluminescent assay (LiCA^®) and compare it with the well-established Architect^® HIV Ag/Ab combo assay in a clinical setting.

Methods

We used banked samples and national reference controls to identify the ability to detect HIV Ag/Ab and different viral subtypes. Thirteen seroconversion panels were tested to evaluate early detection of HIV. A total of 21,042 patient samples were collected to compare the diagnostic performance of LiCA^® with Architect^®. Screening-reactive results were confirmed by Western blotting and nucleic acid testing.

Result

SUBMITTER: Li Y 

PROVIDER: S-EPMC11825764 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature