CD94-driven <i>in vitro</i> expansion of highly functional adaptive NKG2C⁺ NKG2A^- CD57⁺ NK cells from CMV⁺ healthy donors.

ABSTRACT:

Background

Adaptive human natural killer (NK) cells are an NK cell subpopulation arising upon cytomegalovirus (CMV) infection. They are characterized by CD94/NKG2C expression, a mature CD57⁺KIR⁺NKG2A^- phenotype, a prolonged lifespan, and remarkable antitumor functions. In light of these features, adaptive NK cells represent suitable candidate to design next-generation therapies, based on their enhanced effector function which could be further boosted by Chimeric Antigen Receptors-engineering, or the combination with cell engagers. For therapeutic approaches, however, it is key to generate large numbers of functional cells.

Purpose

We developed a method to efficiently expand adaptive NK cells from NK-enriched cell preparations derived from the

SUBMITTER: Giordano C 

PROVIDER: S-EPMC11825780 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature