Sex differences in cardiorespiratory control under hypoxia: the roles of oxygen desaturation and hypoxic exposure time.

ABSTRACT:

Introduction

Males and females differ anatomically and functionally in cardiorespiratory regulation, with males tending to experience greater oxygen desaturation under hypoxia. Therefore, sex might moderate cardiorespiratory responses to acute hypoxia exposure. Accordingly, we hypothesized that sex differences in cardiovascular and ventilatory responses would be more pronounced with equal hypoxia duration (iso-time) but less pronounced at similar oxygen desaturation levels (iso-saturation).

Methods

Twenty-two (12 females) healthy individuals were exposed to normoxia (10 min at FiO₂ = 0.21) and hypoxia (10 min at FiO₂ = 0.115), respectively. Pulse oxygen saturation (SpO₂), R-R intervals, cardiac output, blood pressure (BP), and ventilatory dat

SUBMITTER: Oliveira ALMB 

PROVIDER: S-EPMC11825819 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature