Prognosis and immune infiltration prediction in neuroblastoma based on neutrophil extracellular traps-related gene signature.

ABSTRACT: Neuroblastoma (NB) is a malignant tumor originating from the peripheral sympathetic nervous system and high-risk NB patients have a dismal prognosis. Recent studies have underscored the pivotal role of neutrophil extracellular traps (NETs) in the proliferation, metastasis and immune evasion of cancer. To explore the effect of NETs on NB, we have carried out a systematic analysis and showed several findings in the present work. First, expression profiles along with clinical data were analyzed using the training dataset GSE62564 and 36 NETs-related genes were identified to be significantly associated with overall survival. Following LASSO regression analysis, 11 genes were enrolled to construct the NETs signature, which exhibited a robust predictive capability for overall survival with exhib

SUBMITTER: Aierken Y 

PROVIDER: S-EPMC11825912 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature