A portable and cost-effective system for electronic nucleic acid mass measurement.

ABSTRACT: This paper presents a low-cost, portable sensing platform for rapid DNA mass measurement, addressing a critical need in life science research. The platform features a novel interdigital open-gate junction field-effect transistor (ID-OGJFET) with a large sensing area that converts negatively charged DNA mass into an electrical current. The system enables DNA mass detection in under ten seconds with a resolution of less than 1 µA, demonstrating sensitivity across a range from 0.48 ng to 29.5 ng, achieving a Limit of Detection as low as 1.18-1.25 ng/µL. A custom-designed electronic reader and fluidic sample holder facilitate efficient operation. Simulation studies using molecular dynamics and finite element methods provide further insights into the sensor's DNA detection mechanism. This highl

SUBMITTER: Panahi A 

PROVIDER: S-EPMC11825914 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature